Interventions to improve water quality for preventing diarrhoea: systematic review and meta-analysis
Thomas Clasen, lecturer1, Wolf-Peter Schmidt, clinical research fellow1, Tamer Rabie, public health specialist3, Ian Roberts, professor of epidemiology2, Sandy Cairncross, professor of environmental health1
1 Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, 2 Department of Epidemiology and Public Health, London School of Hygiene and Tropical Medicine, 3 World Bank, Washington, DC, USA
Correspondence to: T Clasen thomas.clasen@lshtm.ac.uk Abstract
Objective To assess the effectiveness of interventions to improve the microbial quality of drinking water for preventing diarrhoea.
Design Systematic review.
Data sources Cochrane Infectious Diseases Group's trials register, CENTRAL, Medline, Embase, LILACS; hand searching; and correspondence with experts and relevant organisations.
Study selection Randomised and quasirandomised controlled trials of interventions to improve the microbial quality of drinking water for preventing diarrhoea in adults and in children in settings with endemic disease.
Data extraction Allocation concealment, blinding, losses to follow-up, type of intervention, outcome measures, and measures of effect. Pooled effect estimates were calculated within the appropriate subgroups.
Data synthesis 33 reports from 21 countries documenting 42 comparisons were included. Variations in design, setting, and type and point of intervention, and variations in defining, assessing, calculating, and reporting outcomes limited the comparability of study results and pooling of results by meta-analysis. In general, interventions to improve the microbial quality of drinking water are effective in preventing diarrhoea. Effectiveness was not conditioned on the presence of improved water supplies or sanitation in the study setting and was not enhanced by combining the intervention with instructions on basic hygiene, a water storage vessel, or improved sanitation or water supplies—other common environmental interventions intended to prevent diarrhoea.
Conclusion Interventions to improve water quality are generally effective for preventing diarrhoea in all ages and in under 5s. Significant heterogeneity among the trials suggests that the level of effectiveness may depend on a variety of conditions that research to date cannot fully explain.
Interventions to improve water quality for preventing diarrhoea: systematic review and meta-analysis
ReplyDeleteThomas Clasen, lecturer1, Wolf-Peter Schmidt, clinical research fellow1, Tamer Rabie, public health specialist3, Ian Roberts, professor of epidemiology2, Sandy Cairncross, professor of environmental health1
1 Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, 2 Department of Epidemiology and Public Health, London School of Hygiene and Tropical Medicine, 3 World Bank, Washington, DC, USA
Correspondence to: T Clasen thomas.clasen@lshtm.ac.uk
Abstract
Objective To assess the effectiveness of interventions to improve the microbial quality of drinking water for preventing diarrhoea.
Design Systematic review.
Data sources Cochrane Infectious Diseases Group's trials register, CENTRAL, Medline, Embase, LILACS; hand searching; and correspondence with experts and relevant organisations.
Study selection Randomised and quasirandomised controlled trials of interventions to improve the microbial quality of drinking water for preventing diarrhoea in adults and in children in settings with endemic disease.
Data extraction Allocation concealment, blinding, losses to follow-up, type of intervention, outcome measures, and measures of effect. Pooled effect estimates were calculated within the appropriate subgroups.
Data synthesis 33 reports from 21 countries documenting 42 comparisons were included. Variations in design, setting, and type and point of intervention, and variations in defining, assessing, calculating, and reporting outcomes limited the comparability of study results and pooling of results by meta-analysis. In general, interventions to improve the microbial quality of drinking water are effective in preventing diarrhoea. Effectiveness was not conditioned on the presence of improved water supplies or sanitation in the study setting and was not enhanced by combining the intervention with instructions on basic hygiene, a water storage vessel, or improved sanitation or water supplies—other common environmental interventions intended to prevent diarrhoea.
Conclusion Interventions to improve water quality are generally effective for preventing diarrhoea in all ages and in under 5s. Significant heterogeneity among the trials suggests that the level of effectiveness may depend on a variety of conditions that research to date cannot fully explain.
Water, sanitation, and hygiene interventions to reduce diarrhoea in less developed countries: a systematic review and meta-analysis
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